The mitotic spindle will not form without it. The mitotic kinase aurora A is required for proper spindle assembly and separation.Īccording to a recent publication, lamin B is a key component of the spindle matrix helping microtubule assembly. Since the center of the spindle specifies the plane along which the cell will divide during cytokinesis, this ensures that each daughter cell will receive one of each chromatid. Once all the chromosomes are aligned with sister chromatids pointing to opposite ends of the spindle, the cell enters anaphase, in which the chromatids separate and move toward their respective poles. The chromosomes are pulled into alignment along the spindle midzone to form the metaphase spindle. At the pointed ends, known as spindle poles, microtubules are nucleated by the centrosomes in the cells of most animals.ĭuring spindle assembly in prometaphase, some of the spindle's microtubules attach to the kinetochores that assemble on the centromere portion of the chromosomes. In the wide middle portion, known as the spindle midzone, antiparallel microtubules are bundled by kinesins. It consists of a bundle of microtubules joined at the ends but spread out in the middle, vaguely ellipsoid in shape. Its function is to segregate chromosomes during cell division (either mitosis or meiosis) to the daughter cells. Some of these microtubules attach to the cell walls. The spindle apparatus is a structure of the eukaryotic cytoskeleton involved in mitosis and meiosis, often referred to as the mitotic spindle during mitosis and the meiotic spindle during meiosis. The spindle apparatus is a network of microtubules that forms within a dividing eukaryotic cell. List of terms related to Spindle apparatusĭuring cell division, the spindle apparatus pulls together the chromosomes into the two daughter cells. Risk calculators and risk factors for Spindle apparatusĬauses & Risk Factors for Spindle apparatus US National Guidelines Clearinghouse on Spindle apparatusĭirections to Hospitals Treating Spindle apparatus Ongoing Trials on Spindle apparatus at Clinical Ĭlinical Trials on Spindle apparatus at Google Most recent articles on Spindle apparatusĪrticles on Spindle apparatus in N Eng J Med, Lancet, BMJĬochrane Collaboration on Spindle apparatus Micrograph showing condensed chromosomes in blue and the mitotic spindle in green during prometaphase of mitosis
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